The story begins about a month and a half after the disaster at the mansion lab. Umbrella Corp develops the T-virus, a muta-genic toxin for the use in biological weapons. After breaking loose, living things mutate into all sorts of decaying creatures.

The case was eventually closed, but Umbrella's experience was far from over. Now it's the worst possible nightmare: a new virus runs rampant. All of Raccoon City is infested. Blood-thirsty zombies, hideous mutations now overwhelm the community. When Leon and Claire arrive in town their nightmare is just beginning. You must control their destiny. If the suspense doesn't kill you, something else will.